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==CRYSTAL STRUCTURE OF THE PTPN4 PDZ DOMAIN COMPLEXED WITH THE PDZ BINDING MOTIF OF THE MITOGEN ACTIVATED PROTEIN KINASE P38GAMMA.==
==CRYSTAL STRUCTURE OF THE PTPN4 PDZ DOMAIN COMPLEXED WITH THE PDZ BINDING MOTIF OF THE MITOGEN ACTIVATED PROTEIN KINASE P38GAMMA.==
<StructureSection load='5ez0' size='340' side='right' caption='[[5ez0]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='5ez0' size='340' side='right'caption='[[5ez0]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ez0]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EZ0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ez0]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EZ0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5eyz|5eyz]], [[3nfk|3nfk]], [[3nfl|3nfl]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPN4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ez0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ez0 OCA], [https://pdbe.org/5ez0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ez0 RCSB], [https://www.ebi.ac.uk/pdbsum/5ez0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ez0 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ez0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ez0 OCA], [http://pdbe.org/5ez0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ez0 RCSB], [http://www.ebi.ac.uk/pdbsum/5ez0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ez0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PTN4_HUMAN PTN4_HUMAN]] May act at junctions between the membrane and the cytoskeleton.  
[https://www.uniprot.org/uniprot/PTN4_HUMAN PTN4_HUMAN] May act at junctions between the membrane and the cytoskeleton.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5ez0" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ez0" style="background-color:#fffaf0;"></div>
==See Also==
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Large Structures]]
[[Category: Caillet-Saguy, C]]
[[Category: Caillet-Saguy C]]
[[Category: Cordier, F]]
[[Category: Cordier F]]
[[Category: Delepierre, M]]
[[Category: Delepierre M]]
[[Category: Lafon, M]]
[[Category: Lafon M]]
[[Category: Maisonneuve, P]]
[[Category: Maisonneuve P]]
[[Category: Vaney, M C]]
[[Category: Vaney MC]]
[[Category: Wolff, N]]
[[Category: Wolff N]]
[[Category: Apoptosis]]
[[Category: Cell death]]
[[Category: Glioblastoma]]
[[Category: Mitogen activated protein kinase]]
[[Category: Multiprotein complex]]
[[Category: Non-receptor type 4]]
[[Category: P38gamma]]
[[Category: Pdz binding motif]]
[[Category: Pdz domain]]
[[Category: Protein binding]]
[[Category: Ptpn4]]
[[Category: Rabies virus]]
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