5f5z: Difference between revisions
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<StructureSection load='5f5z' size='340' side='right'caption='[[5f5z]], [[Resolution|resolution]] 1.76Å' scene=''> | <StructureSection load='5f5z' size='340' side='right'caption='[[5f5z]], [[Resolution|resolution]] 1.76Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5f5z]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F5Z OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5f5z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F5Z FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5VY:2-METHYL-~{N}-[3-[[5-METHYL-2-[[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO]PYRIMIDIN-4-YL]AMINO]PHENYL]PROPANE-2-SULFONAMIDE'>5VY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.76Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5VY:2-METHYL-~{N}-[3-[[5-METHYL-2-[[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO]PYRIMIDIN-4-YL]AMINO]PHENYL]PROPANE-2-SULFONAMIDE'>5VY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f5z OCA], [https://pdbe.org/5f5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f5z RCSB], [https://www.ebi.ac.uk/pdbsum/5f5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f5z ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ember | [[Category: Ember SW]] | ||
[[Category: Schonbrunn | [[Category: Schonbrunn E]] | ||
[[Category: Zhu | [[Category: Zhu J-Y]] | ||
Latest revision as of 06:39, 19 July 2023
Crystal structure of the first bromodomain of human BRD4 in complex with MA2-014
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