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==Mouse importin alpha: Dengue 3 NS5 C-terminal NLS peptide complex==
==Mouse importin alpha: Dengue 3 NS5 C-terminal NLS peptide complex==
<StructureSection load='5fc8' size='340' side='right' caption='[[5fc8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='5fc8' size='340' side='right'caption='[[5fc8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5fc8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FC8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5fc8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FC8 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kpna2, Rch1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fc8 OCA], [http://pdbe.org/5fc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fc8 RCSB], [http://www.ebi.ac.uk/pdbsum/5fc8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fc8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fc8 OCA], [https://pdbe.org/5fc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fc8 RCSB], [https://www.ebi.ac.uk/pdbsum/5fc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fc8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE]] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
[https://www.uniprot.org/uniprot/B6VDJ7_9FLAV B6VDJ7_9FLAV]  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Importin|Importin]]
*[[Importin 3D structures|Importin 3D structures]]
*[[Nonstructural protein|Nonstructural protein]]
*[[Nonstructural protein 3D structures|Nonstructural protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Dengue virus 3]]
[[Category: Dengue virus 3]]
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Forwood, J K]]
[[Category: Mus musculus]]
[[Category: Smith, K M]]
[[Category: Forwood JK]]
[[Category: Dengue]]
[[Category: Smith KM]]
[[Category: Importin]]
[[Category: Ns5]]
[[Category: Protein transport-viral protein complex]]
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