2heo: Difference between revisions

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<StructureSection load='2heo' size='340' side='right'caption='[[2heo]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='2heo' size='340' side='right'caption='[[2heo]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2heo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HEO FirstGlance]. <br>
<table><tr><td colspan='2'>[[2heo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HEO FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1j75|1j75]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Zbp1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2heo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2heo OCA], [https://pdbe.org/2heo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2heo RCSB], [https://www.ebi.ac.uk/pdbsum/2heo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2heo ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2heo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2heo OCA], [https://pdbe.org/2heo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2heo RCSB], [https://www.ebi.ac.uk/pdbsum/2heo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2heo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ZBP1_MOUSE ZBP1_MOUSE]] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3.<ref>PMID:17618271</ref> <ref>PMID:19590578</ref>
[https://www.uniprot.org/uniprot/ZBP1_MOUSE ZBP1_MOUSE] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3.<ref>PMID:17618271</ref> <ref>PMID:19590578</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Charbonnier, J B]]
[[Category: Charbonnier JB]]
[[Category: Cuniasse, P]]
[[Category: Cuniasse P]]
[[Category: Du, M H.Le]]
[[Category: Gasparini S]]
[[Category: Gasparini, S]]
[[Category: Le Du MH]]
[[Category: Magis, C]]
[[Category: Magis C]]
[[Category: Menez, A]]
[[Category: Menez A]]
[[Category: Stura, E]]
[[Category: Stura E]]
[[Category: Immune system-dna complex]]
[[Category: Protein dlm1-z-dna complex]]
Retrieved from "https://proteopedia.org/2heo"