2rsy: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
Line 1: Line 1:


==Solution structure of the SH2 domain of Csk in complex with a phosphopeptide from Cbp==
==Solution structure of the SH2 domain of Csk in complex with a phosphopeptide from Cbp==
<StructureSection load='2rsy' size='340' side='right'caption='[[2rsy]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2rsy' size='340' side='right'caption='[[2rsy]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2rsy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RSY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RSY FirstGlance]. <br>
<table><tr><td colspan='2'>[[2rsy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RSY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RSY FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Csk ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Pag1, Cbp, Pag ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rsy OCA], [https://pdbe.org/2rsy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rsy RCSB], [https://www.ebi.ac.uk/pdbsum/2rsy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rsy ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rsy OCA], [https://pdbe.org/2rsy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rsy RCSB], [https://www.ebi.ac.uk/pdbsum/2rsy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rsy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CSK_RAT CSK_RAT]] Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity).<ref>PMID:1722201</ref> <ref>PMID:7515063</ref> [[https://www.uniprot.org/uniprot/PHAG1_RAT PHAG1_RAT]] Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.<ref>PMID:10801129</ref> <ref>PMID:10918051</ref> <ref>PMID:11859092</ref> 
[https://www.uniprot.org/uniprot/CSK_RAT CSK_RAT] Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity).<ref>PMID:1722201</ref> <ref>PMID:7515063</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 27: Line 26:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Rattus norvegicus]]
[[Category: Akagi, K]]
[[Category: Akagi K]]
[[Category: Debenecker, M]]
[[Category: Debenecker M]]
[[Category: Ikegami, T]]
[[Category: Ikegami T]]
[[Category: Kanou, T]]
[[Category: Kanou T]]
[[Category: Lee, Y]]
[[Category: Lee Y]]
[[Category: Nakagawa, A]]
[[Category: Nakagawa A]]
[[Category: Okada, M]]
[[Category: Okada M]]
[[Category: Oneyama, C]]
[[Category: Oneyama C]]
[[Category: Sasaki, Y]]
[[Category: Sasaki Y]]
[[Category: Tanaka, H]]
[[Category: Tanaka H]]
[[Category: Tanaka, M]]
[[Category: Tanaka M]]
[[Category: Yokogawa, D]]
[[Category: Yokogawa D]]
[[Category: Cbp]]
[[Category: Csk]]
[[Category: Sh2 domain]]
[[Category: Solution structure]]
[[Category: Transferase-signaling protein complex]]
Retrieved from "https://proteopedia.org/2rsy"