5fp0: Difference between revisions

<table><tr><td colspan='2'>[[5fp0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FP0 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SZC:N-CYCLOPENTYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-3H-BENZIMIDAZOLE-4-SULFONAMIDE'>SZC</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fp0 OCA], [https://pdbe.org/5fp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fp0 RCSB], [https://www.ebi.ac.uk/pdbsum/5fp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fp0 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/HYES_HUMAN HYES_HUMAN] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.<ref>PMID:12574508</ref> <ref>PMID:12574510</ref>  

[[Category: Homo sapiens]]

[[Category: Backstrom S]]

[[Category: Beisel HG]]

[[Category: Johansson CA]]

[[Category: Karis D]]

[[Category: Olsson T]]

[[Category: Oster L]]

[[Category: Rohman M]]

[[Category: Xue Y]]