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'''THREE-DIMENSIONAL STRUCTURE OF THE LDL RECEPTOR-BINDING DOMAIN OF HUMAN APOLIPOPROTEIN E''' | '''THREE-DIMENSIONAL STRUCTURE OF THE LDL RECEPTOR-BINDING DOMAIN OF HUMAN APOLIPOPROTEIN E''' | ||
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[[Category: Agard, D A.]] | [[Category: Agard, D A.]] | ||
[[Category: Wilson, C.]] | [[Category: Wilson, C.]] | ||
[[Category: | [[Category: Lipoprotein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:08:50 2008'' | |||
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Revision as of 21:08, 2 May 2008
THREE-DIMENSIONAL STRUCTURE OF THE LDL RECEPTOR-BINDING DOMAIN OF HUMAN APOLIPOPROTEIN E
Overview
Human apolipoprotein E, a blood plasma protein, mediates the transport and uptake of cholesterol and lipid by way of its high affinity interaction with different cellular receptors, including the low-density lipoprotein (LDL) receptor. The three-dimensional structure of the LDL receptor-binding domain of apoE has been determined at 2.5 angstrom resolution by x-ray crystallography. The protein forms an unusually elongated (65 angstroms) four-helix bundle, with the helices apparently stabilized by a tightly packed hydrophobic core that includes leucine zipper-type interactions and by numerous salt bridges on the mostly charged surface. Basic amino acids important for LDL receptor binding are clustered into a surface patch on one long helix. This structure provides the basis for understanding the behavior of naturally occurring mutants that can lead to atherosclerosis.
About this Structure
1LPE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E., Wilson C, Wardell MR, Weisgraber KH, Mahley RW, Agard DA, Science. 1991 Jun 28;252(5014):1817-22. PMID:2063194 Page seeded by OCA on Sat May 3 00:08:50 2008
