8dnd: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8dnd is ~~ON HOLD until Paper Publication~~

==Crystal structure of Bothrops pirajai Piratoxin-I (PrTX-I) and synthetic inhibitor Varespladib (LY315920)==

~~Authors~~: ~~Salvador~~, G.H.M., ~~Fontes~~, M.R.M.

== Structural highlights ==

<table><tr><td colspan='2'>[[8dnd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bothrops_pirajai Bothrops pirajai]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DND OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8DND FirstGlance].

~~Description~~: ~~Crystal structure of Bothrops pirajai Piratoxin-I~~ (~~PrTX~~-I) and ~~synthetic inhibitor Varespladib~~ (~~LY315920~~)

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.018Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VRD:({3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-indol-4-yl}oxy)acetic+acid'>VRD</scene></td></tr>

[[Category: ~~Salvador, G.H.M~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8dnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dnd OCA], [https://pdbe.org/8dnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dnd RCSB], [https://www.ebi.ac.uk/pdbsum/8dnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dnd ProSAT]</td></tr>

[[Category: ~~Fontes, M.R.M~~]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/PA2H1_BOTPI PA2H1_BOTPI] Snake venom phospholipase A2 (PLA2) homolog that lacks enzymatic activity, but displays myotoxin and edema-inducing activities in vivo. In vitro neuromuscular activities have also been observed, but they are not found in vivo and can be explained by the destabilization of the muscle membrane by the toxin. The myotoxic activity is inhibited by rosmarinic acid (RA).<ref>PMID:7660366</ref> <ref>PMID:22205953</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Bothrops pirajai]]

[[Category: Large Structures]]

[[Category: Fontes MRM]]

[[Category: Salvador GHM]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8dnd is ON HOLD  until Paper Publication
+==Crystal structure of Bothrops pirajai Piratoxin-I (PrTX-I) and synthetic inhibitor Varespladib (LY315920)==
+<StructureSection load='8dnd' size='340' side='right'caption='[[8dnd]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
-Authors: Salvador, G.H.M., Fontes, M.R.M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8dnd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bothrops_pirajai Bothrops pirajai]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DND FirstGlance]. <br>
-Description: Crystal structure of Bothrops pirajai Piratoxin-I (PrTX-I) and synthetic inhibitor Varespladib (LY315920)
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.018&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VRD:({3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-indol-4-yl}oxy)acetic+acid'>VRD</scene></td></tr>
-[[Category: Salvador, G.H.M]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dnd OCA], [https://pdbe.org/8dnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dnd RCSB], [https://www.ebi.ac.uk/pdbsum/8dnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dnd ProSAT]</span></td></tr>
-[[Category: Fontes, M.R.M]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PA2H1_BOTPI PA2H1_BOTPI] Snake venom phospholipase A2 (PLA2) homolog that lacks enzymatic activity, but displays myotoxin and edema-inducing activities in vivo. In vitro neuromuscular activities have also been observed, but they are not found in vivo and can be explained by the destabilization of the muscle membrane by the toxin. The myotoxic activity is inhibited by rosmarinic acid (RA).<ref>PMID:7660366</ref> <ref>PMID:22205953</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Bothrops pirajai]]
+[[Category: Large Structures]]
+[[Category: Fontes MRM]]
+[[Category: Salvador GHM]]