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==Crystal Structure of Drosophila melanogaster Dopamine N-Acetyltransferase in Ternary Complex with CoA and Acetyl-dopamine==
==Crystal Structure of Drosophila melanogaster Dopamine N-Acetyltransferase in Ternary Complex with CoA and Acetyl-dopamine==
<StructureSection load='5gi8' size='340' side='right' caption='[[5gi8]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
<StructureSection load='5gi8' size='340' side='right'caption='[[5gi8]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5gi8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GI8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GI8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5gi8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GI8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7DP:~{N}-[2-[3,4-bis(oxidanyl)phenyl]ethyl]ethanamide'>7DP</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=D1D:(4S,5S)-1,2-DITHIANE-4,5-DIOL'>D1D</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5gi5|5gi5]], [[5gi6|5gi6]], [[5gi7|5gi7]], [[5gi9|5gi9]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7DP:~{N}-[2-[3,4-bis(oxidanyl)phenyl]ethyl]ethanamide'>7DP</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=D1D:(4S,5S)-1,2-DITHIANE-4,5-DIOL'>D1D</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Dat, NAT1, CG3318 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gi8 OCA], [https://pdbe.org/5gi8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gi8 RCSB], [https://www.ebi.ac.uk/pdbsum/5gi8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gi8 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aralkylamine_N-acetyltransferase Aralkylamine N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.87 2.3.1.87] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gi8 OCA], [http://pdbe.org/5gi8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gi8 RCSB], [http://www.ebi.ac.uk/pdbsum/5gi8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gi8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DNAT_DROME DNAT_DROME]] Catalyzes N-acetylation of tryptamine, tyramine, dopamine, serotonin and octopamine. Is not essential for sclerotization.<ref>PMID:8901578</ref> <ref>PMID:9703021</ref> <ref>PMID:7498465</ref>
[https://www.uniprot.org/uniprot/DNAT_DROME DNAT_DROME] Catalyzes N-acetylation of tryptamine, tyramine, dopamine, serotonin and octopamine. Is not essential for sclerotization.<ref>PMID:8901578</ref> <ref>PMID:9703021</ref> <ref>PMID:7498465</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Aralkylamine N-acetyltransferase]]
[[Category: Drosophila melanogaster]]
[[Category: Drome]]
[[Category: Large Structures]]
[[Category: Cheng, H C]]
[[Category: Cheng HC]]
[[Category: Cheng, K C]]
[[Category: Cheng KC]]
[[Category: Lin, S J]]
[[Category: Lin SJ]]
[[Category: Lyu, P C]]
[[Category: Lyu PC]]
[[Category: Yang, Y C]]
[[Category: Yang YC]]
[[Category: Order bi-bi sequential mechanism]]
[[Category: Transferase]]

Latest revision as of 11:32, 2 August 2023

Crystal Structure of Drosophila melanogaster Dopamine N-Acetyltransferase in Ternary Complex with CoA and Acetyl-dopamine

5gi8, resolution 1.30Å

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