1hfd: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1hfd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HFD FirstGlance]. <br>
<table><tr><td colspan='2'>[[1hfd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HFD FirstGlance]. <br>
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Complement_factor_D Complement factor D], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.46 3.4.21.46] </span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hfd OCA], [https://pdbe.org/1hfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hfd RCSB], [https://www.ebi.ac.uk/pdbsum/1hfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hfd ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hfd OCA], [https://pdbe.org/1hfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hfd RCSB], [https://www.ebi.ac.uk/pdbsum/1hfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hfd ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/CFAD_HUMAN CFAD_HUMAN]] Defects in CFD are the cause of complement factor D deficiency (CFDD) [MIM:[https://omim.org/entry/613912 613912]]. CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.  
[https://www.uniprot.org/uniprot/CFAD_HUMAN CFAD_HUMAN] Defects in CFD are the cause of complement factor D deficiency (CFDD) [MIM:[https://omim.org/entry/613912 613912]. CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CFAD_HUMAN CFAD_HUMAN]] Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.  
[https://www.uniprot.org/uniprot/CFAD_HUMAN CFAD_HUMAN] Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Complement factor D]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Babu, Y S]]
[[Category: Babu YS]]
[[Category: Jing, H]]
[[Category: Jing H]]
[[Category: Kilpatrick, J M]]
[[Category: Kilpatrick JM]]
[[Category: Liu, X Y]]
[[Category: Liu X-Y]]
[[Category: Moore, D]]
[[Category: Moore D]]
[[Category: Narayana, S V.L]]
[[Category: Narayana SVL]]
[[Category: Volanakis, J E]]
[[Category: Volanakis JE]]
[[Category: Catalytic triad]]
[[Category: Complement]]
[[Category: Factor d]]
[[Category: Hydrolase]]
[[Category: Self-regulation]]
[[Category: Serine protease]]
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