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<StructureSection load='1mel' size='340' side='right'caption='[[1mel]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='1mel' size='340' side='right'caption='[[1mel]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1mel]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabian_camel Arabian camel] and [http://en.wikipedia.org/wiki/Chick Chick]. The April 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nanobodies''  by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_4 10.2210/rcsb_pdb/mom_2011_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MEL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1MEL FirstGlance]. <br>
<table><tr><td colspan='2'>[[1mel]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius] and [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. The April 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nanobodies''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_4 10.2210/rcsb_pdb/mom_2011_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MEL FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ANTIBODY VH FRAGMENT CAB-LYS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9838 Arabian camel]), ANTIBODY VH FRAGMENT CAB-LYS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mel OCA], [https://pdbe.org/1mel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mel RCSB], [https://www.ebi.ac.uk/pdbsum/1mel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mel ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1mel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mel OCA], [http://pdbe.org/1mel PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mel RCSB], [http://www.ebi.ac.uk/pdbsum/1mel PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mel ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arabian camel]]
[[Category: Camelus dromedarius]]
[[Category: Chick]]
[[Category: Gallus gallus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lysozyme]]
[[Category: Nanobodies]]
[[Category: Nanobodies]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Desmyter, A]]
[[Category: Arbabi Gharoudi M]]
[[Category: Gharoudi, M Arbabi]]
[[Category: Dao Thi M]]
[[Category: Hamers, R]]
[[Category: Desmyter A]]
[[Category: Muyldermans, S]]
[[Category: Hamers R]]
[[Category: Poortmans, F]]
[[Category: Muyldermans S]]
[[Category: Thi, M Dao]]
[[Category: Poortmans F]]
[[Category: Transue, T R]]
[[Category: Transue TR]]
[[Category: Wyns, L]]
[[Category: Wyns L]]
[[Category: Camel single-domain anti-lysozyme]]

Revision as of 06:29, 9 August 2023

CRYSTAL STRUCTURE OF A CAMEL SINGLE-DOMAIN VH ANTIBODY FRAGMENT IN COMPLEX WITH LYSOZYME

1mel, resolution 2.50Å

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