2dab: Difference between revisions

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<StructureSection load='2dab' size='340' side='right'caption='[[2dab]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2dab' size='340' side='right'caption='[[2dab]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2dab]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacym Bacym]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DAB FirstGlance]. <br>
<table><tr><td colspan='2'>[[2dab]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_sp._YM-1 Bacillus sp. YM-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DAB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/D-amino-acid_transaminase D-amino-acid transaminase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.21 2.6.1.21] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dab OCA], [https://pdbe.org/2dab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dab RCSB], [https://www.ebi.ac.uk/pdbsum/2dab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dab ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dab OCA], [https://pdbe.org/2dab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dab RCSB], [https://www.ebi.ac.uk/pdbsum/2dab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dab ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DAAA_BACYM DAAA_BACYM]] Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction. The second-half reaction is the reverse of the first, transferring the amino group from the pyridoxamine to a second alpha-keto acid to form the product D-amino acid via a ping-pong mechanism. This is an important process in the formation of D-alanine and D-glutamate, which are essential bacterial cell wall components.<ref>PMID:2914916</ref> <ref>PMID:9538014</ref>
[https://www.uniprot.org/uniprot/DAAA_BACYM DAAA_BACYM] Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction. The second-half reaction is the reverse of the first, transferring the amino group from the pyridoxamine to a second alpha-keto acid to form the product D-amino acid via a ping-pong mechanism. This is an important process in the formation of D-alanine and D-glutamate, which are essential bacterial cell wall components.<ref>PMID:2914916</ref> <ref>PMID:9538014</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacym]]
[[Category: Bacillus sp. YM-1]]
[[Category: D-amino-acid transaminase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Esaki, N]]
[[Category: Esaki N]]
[[Category: Kashima, A]]
[[Category: Kashima A]]
[[Category: Kishimoto, K]]
[[Category: Kishimoto K]]
[[Category: Peisach, D]]
[[Category: Peisach D]]
[[Category: Petsko, G A]]
[[Category: Petsko GA]]
[[Category: Ringe, D]]
[[Category: Ringe D]]
[[Category: Sugio, S]]
[[Category: Sugio S]]
[[Category: Yoshimura, T]]
[[Category: Yoshimura T]]
[[Category: Alpha-ketoglutamic acid]]
[[Category: Aminotransferase]]
[[Category: D-alanine]]
[[Category: D-amino acid]]
[[Category: Pyridoxal-5'-phosphate]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/2dab"