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==NMR structure of the alpha-conotoxin GI (ASN4)-benzoylphenylalanine derivative==
==NMR structure of the alpha-conotoxin GI (ASN4)-benzoylphenylalanine derivative==
<StructureSection load='2frb' size='340' side='right'caption='[[2frb]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2frb' size='340' side='right'caption='[[2frb]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2frb]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FRB FirstGlance]. <br>
<table><tr><td colspan='2'>[[2frb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_geographus Conus geographus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FRB FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PBF:PARA-(BENZOYL)-PHENYLALANINE'>PBF</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PBF:PARA-(BENZOYL)-PHENYLALANINE'>PBF</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2frb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2frb OCA], [https://pdbe.org/2frb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2frb RCSB], [https://www.ebi.ac.uk/pdbsum/2frb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2frb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2frb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2frb OCA], [https://pdbe.org/2frb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2frb RCSB], [https://www.ebi.ac.uk/pdbsum/2frb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2frb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/CA1A_CONGE CA1A_CONGE]] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. The higher affinity site for alpha-conotoxin GI is the alpha/delta site on mouse muscle-derived BC3H-1 receptor, and the other site (alpha/gamma site) on nicotinic receptors from Torpedo californica electric organ.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Conus geographus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arseniev, A S]]
[[Category: Arseniev AS]]
[[Category: Kasheverov, I V]]
[[Category: Kasheverov IV]]
[[Category: Maslennikov, I]]
[[Category: Maslennikov I]]
[[Category: Pashkov, V S]]
[[Category: Pashkov VS]]
[[Category: Tsetlin, V I]]
[[Category: Tsetlin VI]]
[[Category: Utkin, Y N]]
[[Category: Utkin YN]]
[[Category: Zhmak, M N]]
[[Category: Zhmak MN]]
[[Category: Alpha-conotoxin gi]]
[[Category: Benzophenone analog]]
[[Category: Nicotinic acetylcholine receptor antagonist]]
[[Category: Toxin]]
Retrieved from "https://proteopedia.org/2frb"