5haf: Difference between revisions

<table><tr><td colspan='2'>[[5haf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HAF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HAF FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5haf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5haf OCA], [https://pdbe.org/5haf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5haf RCSB], [https://www.ebi.ac.uk/pdbsum/5haf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5haf ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/SSEL_SALTY SSEL_SALTY] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells. Specifically hydrolyzes mono- and polyubiquitin substrates in vitro with a preference for 'Lys-63'-linked ubiquitin chains, suggesting that it interferes with a signaling pathway rather than inhibiting proteasomal-dependent degradation of its targets. Does not possess desumoylating activity. Is required for the Salmonella-induced delayed cytotoxicity in macrophages and full virulence. Is not required for intracellular bacterial replication.<ref>PMID:17158898</ref> <ref>PMID:17360673</ref>  

[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]

[[Category: Komander D]]

[[Category: Pruneda JN]]