5hfc: Difference between revisions

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<StructureSection load='5hfc' size='340' side='right'caption='[[5hfc]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='5hfc' size='340' side='right'caption='[[5hfc]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5hfc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HFC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5HFC FirstGlance]. <br>
<table><tr><td colspan='2'>[[5hfc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HFC FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1be9|1be9]], [[5hdy|5hdy]], [[5heb|5heb]], [[5hed|5hed]], [[5het|5het]], [[5hey|5hey]], [[5hf1|5hf1]], [[5hf4|5hf4]], [[5hfb|5hfb]], [[5hfd|5hfd]], [[5hfe|5hfe]], [[5hff|5hff]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.851&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Dlg4, Dlgh4, Psd95 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hfc OCA], [https://pdbe.org/5hfc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hfc RCSB], [https://www.ebi.ac.uk/pdbsum/5hfc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hfc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5hfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hfc OCA], [http://pdbe.org/5hfc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hfc RCSB], [http://www.ebi.ac.uk/pdbsum/5hfc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hfc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref> [[http://www.uniprot.org/uniprot/CRIPT_RAT CRIPT_RAT]] Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses.<ref>PMID:10570482</ref> <ref>PMID:9581762</ref> 
[https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Glycoprotein GP 3D structures|Glycoprotein GP 3D structures]]
*[[Glycoprotein GP 3D structures|Glycoprotein GP 3D structures]]
*[[Postsynaptic density protein 3D structures|Postsynaptic density protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Raman, A S]]
[[Category: Rattus norvegicus]]
[[Category: Ranganathan, R]]
[[Category: Raman AS]]
[[Category: White, K I]]
[[Category: Ranganathan R]]
[[Category: Adhesion]]
[[Category: White KI]]
[[Category: Dhr]]
[[Category: Glgf]]
[[Category: Pdz]]
[[Category: Peptide binding protein]]
[[Category: Peptide-binding domain]]
[[Category: Synapse]]
[[Category: Synaptic density]]
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