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| | | #REDIRECT [[8pc5]] This PDB entry is obsolete and replaced by 8pc5 |
| ==H3K36 tri-methylated nucleosome LEDGF PWWP domain complex==
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| <StructureSection load='7pgv' size='340' side='right'caption='[[7pgv]], [[Resolution|resolution]] 3.40Å' scene=''>
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| == Structural highlights ==
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| <table><tr><td colspan='2'>[[7pgv]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PGV FirstGlance]. <br>
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| </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ML3:2-{[(2R)-2-AMINO-2-CARBOXYETHYL]SULFANYL}-N,N,N-TRIMETHYLETHANAMINIUM'>ML3</scene></td></tr>
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| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pgv OCA], [https://pdbe.org/7pgv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pgv RCSB], [https://www.ebi.ac.uk/pdbsum/7pgv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pgv ProSAT]</span></td></tr>
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| </table>
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| == Function ==
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| [https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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| __TOC__
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| </StructureSection>
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| [[Category: Homo sapiens]]
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| [[Category: Large Structures]]
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| [[Category: Synthetic construct]]
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| [[Category: Xenopus laevis]]
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| [[Category: Hexnerova R]]
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| [[Category: Koutna E]]
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| [[Category: Lux V]]
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| [[Category: Novacek J]]
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| [[Category: Poepsel S]]
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| [[Category: Skerlova J]]
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| [[Category: Srb P]]
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| [[Category: Veverka V]]
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This PDB entry is obsolete and replaced by 8pc5
