8imy: Difference between revisions
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The entry | ==Cryo-EM structure of GPI-T (inactive mutant) with GPI and proULBP2, a proprotein substrate== | ||
<StructureSection load='8imy' size='340' side='right'caption='[[8imy]], [[Resolution|resolution]] 3.22Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8imy]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Clavularia_sp. Clavularia sp.] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IMY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IMY FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.22Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=05E:2-azanylethyl+[(2~{S},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl]+hydrogen+phosphate'>05E</scene>, <scene name='pdbligand=6OU:[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl]+(~{Z})-octadec-9-enoate'>6OU</scene>, <scene name='pdbligand=80T:[(2R)-1-hexadecanoyloxy-3-[[3-[[(2R)-3-hexadecanoyloxy-2-[(Z)-octadec-9-enoyl]oxy-propoxy]-oxidanyl-phosphoryl]oxy-2-oxidanyl-propoxy]-oxidanyl-phosphoryl]oxy-propan-2-yl]+(Z)-octadec-9-enoate'>80T</scene>, <scene name='pdbligand=80Y:2-azanylethyl+[(2R,3S,4S,5S,6S)-3,4,5,6-tetrakis(oxidanyl)oxan-2-yl]methyl+hydrogen+phosphate'>80Y</scene>, <scene name='pdbligand=81Q:[(2R)-1-[[(1S,2R,3R,4S,5S,6R)-2-hexadecanoyloxy-3,4,5,6-tetrakis(oxidanyl)cyclohexyl]oxy-oxidanyl-phosphoryl]oxy-3-octadecoxy-propan-2-yl]+(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate'>81Q</scene>, <scene name='pdbligand=AJP:Digitonin'>AJP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=LBN:1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine'>LBN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PA1:2-AMINO-2-DEOXY-ALPHA-D-GLUCOPYRANOSE'>PA1</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8imy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8imy OCA], [https://pdbe.org/8imy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8imy RCSB], [https://www.ebi.ac.uk/pdbsum/8imy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8imy ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/GPAA1_HUMAN GPAA1_HUMAN] Neurodevelopmental delay-seizures-ophthalmic anomalies-osteopenia-cerebellar atrophy syndrome. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GFPL_CLASP GFPL_CLASP] [https://www.uniprot.org/uniprot/GPAA1_HUMAN GPAA1_HUMAN] Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate.<ref>PMID:29100095</ref> <ref>PMID:9468317</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Clavularia sp]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Li D]] | |||
[[Category: Li T]] | |||
[[Category: Qu Q]] | |||
[[Category: Xu Y]] | |||
Revision as of 08:25, 16 August 2023
Cryo-EM structure of GPI-T (inactive mutant) with GPI and proULBP2, a proprotein substrate
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