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<StructureSection load='1ko0' size='340' side='right'caption='[[1ko0]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='1ko0' size='340' side='right'caption='[[1ko0]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1ko0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KO0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1KO0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1ko0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KO0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KO0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DLY:D-LYSINE'>DLY</scene>, <scene name='pdbligand=LYS:LYSINE'>LYS</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1knw|1knw]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DLY:D-LYSINE'>DLY</scene>, <scene name='pdbligand=LYS:LYSINE'>LYS</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lysA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ko0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ko0 OCA], [https://pdbe.org/1ko0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ko0 RCSB], [https://www.ebi.ac.uk/pdbsum/1ko0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ko0 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diaminopimelate_decarboxylase Diaminopimelate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.20 4.1.1.20] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1ko0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ko0 OCA], [http://pdbe.org/1ko0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ko0 RCSB], [http://www.ebi.ac.uk/pdbsum/1ko0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ko0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DCDA_ECOLI DCDA_ECOLI]] Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. Is not active against the DD- or LL-isomers of diaminopimelate.<ref>PMID:14343156</ref> <ref>PMID:11856852</ref> <ref>PMID:18508763</ref>
[https://www.uniprot.org/uniprot/DCDA_ECOLI DCDA_ECOLI] Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. Is not active against the DD- or LL-isomers of diaminopimelate.<ref>PMID:14343156</ref> <ref>PMID:11856852</ref> <ref>PMID:18508763</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Diaminopimelate decarboxylase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Blagova, L]]
[[Category: Blagova L]]
[[Category: Bose, N]]
[[Category: Bose N]]
[[Category: Levdikov, V]]
[[Category: Levdikov V]]
[[Category: Momany, C]]
[[Category: Momany C]]
[[Category: Diaminopimelate]]
[[Category: Lyase]]
[[Category: Lysine]]
[[Category: Plp]]
[[Category: Pyridoxal-5'-phosphate]]
[[Category: Tim-barrel]]

Latest revision as of 09:01, 16 August 2023

Crystal Structure of a D,L-lysine complex of diaminopimelate decarboxylase

1ko0, resolution 2.20Å

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