1l2j: Difference between revisions

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<StructureSection load='1l2j' size='340' side='right'caption='[[1l2j]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
<StructureSection load='1l2j' size='340' side='right'caption='[[1l2j]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1l2j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L2J FirstGlance]. <br>
<table><tr><td colspan='2'>[[1l2j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L2J FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ETC:(R,R)-5,11-CIS-DIETHYL-5,6,11,12-TETRAHYDROCHRYSENE-2,8-DIOL'>ETC</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qkm|1qkm]], [[1l2i|1l2i]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ETC:(R,R)-5,11-CIS-DIETHYL-5,6,11,12-TETRAHYDROCHRYSENE-2,8-DIOL'>ETC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2j OCA], [https://pdbe.org/1l2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l2j RCSB], [https://www.ebi.ac.uk/pdbsum/1l2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l2j ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2j OCA], [https://pdbe.org/1l2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l2j RCSB], [https://www.ebi.ac.uk/pdbsum/1l2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l2j ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN]] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.  
[https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Agard, D A]]
[[Category: Agard DA]]
[[Category: Barstad, D]]
[[Category: Barstad D]]
[[Category: Greene, G L]]
[[Category: Greene GL]]
[[Category: Katzenellenbogen, B S]]
[[Category: Katzenellenbogen BS]]
[[Category: Katzenellenbogen, J A]]
[[Category: Katzenellenbogen JA]]
[[Category: Meyers, M J]]
[[Category: Meyers MJ]]
[[Category: Nettles, K W]]
[[Category: Nettles KW]]
[[Category: Radek, J T]]
[[Category: Radek JT]]
[[Category: Shiau, A K]]
[[Category: Shiau AK]]
[[Category: Antagonist]]
[[Category: Estrogen]]
[[Category: Nuclear receptor]]
[[Category: Transcription factor]]
[[Category: Transcription receptor]]
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