1ryv: Difference between revisions
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==Three dimensional solution structure of the K27A MUTANT of sodium channels inhibitor HAINANTOXIN-IV BY 2D 1H-NMR== | ==Three dimensional solution structure of the K27A MUTANT of sodium channels inhibitor HAINANTOXIN-IV BY 2D 1H-NMR== | ||
<StructureSection load='1ryv' size='340' side='right'caption='[[1ryv | <StructureSection load='1ryv' size='340' side='right'caption='[[1ryv]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1ryv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RYV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RYV FirstGlance]. <br> | <table><tr><td colspan='2'>[[1ryv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haplopelma_hainanum Haplopelma hainanum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RYV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RYV FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ryv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ryv OCA], [https://pdbe.org/1ryv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ryv RCSB], [https://www.ebi.ac.uk/pdbsum/1ryv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ryv ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ryv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ryv OCA], [https://pdbe.org/1ryv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ryv RCSB], [https://www.ebi.ac.uk/pdbsum/1ryv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ryv ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/H4A01_CYRHA H4A01_CYRHA] Neurotoxin that selectively inhibits neuronal tetrodotoxin-sensitive voltage-gated sodium channels (Nav) (IC(50)=44.6 nM) (PubMed:14512091, PubMed:12518233). It is active on Nav1.2/SCN2A (IC(50)=22.4 nM), Nav1.6/SCN8A (IC(50)=50.1 nM) and Nav1.7/SCN9A (IC(50)=48.9 nM) (PubMed:29703751). It shows low affinity for lipid bilayers (PubMed:29703751).<ref>PMID:12518233</ref> <ref>PMID:12827284</ref> <ref>PMID:14512091</ref> <ref>PMID:29703751</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Haplopelma hainanum]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Gu | [[Category: Gu X]] | ||
[[Category: Li | [[Category: Li D]] | ||
[[Category: Liang | [[Category: Liang S]] | ||
[[Category: Lu | [[Category: Lu S]] | ||
