5hm3: Difference between revisions

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<StructureSection load='5hm3' size='340' side='right'caption='[[5hm3]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='5hm3' size='340' side='right'caption='[[5hm3]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5hm3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HM3 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5HM3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5hm3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HM3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HM3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=649:5-O-[(11-PHENOXYUNDECANOYL)SULFAMOYL]ADENOSINE'>649</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=649:5-O-[(11-PHENOXYUNDECANOYL)SULFAMOYL]ADENOSINE'>649</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fadD32, Rv3801c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hm3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hm3 OCA], [https://pdbe.org/5hm3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hm3 RCSB], [https://www.ebi.ac.uk/pdbsum/5hm3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hm3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5hm3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hm3 OCA], [http://pdbe.org/5hm3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hm3 RCSB], [http://www.ebi.ac.uk/pdbsum/5hm3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hm3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FAA32_MYCTU FAA32_MYCTU]] Catalyzes the activation of long-chain fatty acids as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase (PKS) for further chain extension.<ref>PMID:15042094</ref>
[https://www.uniprot.org/uniprot/FAA32_MYCTU FAA32_MYCTU] Catalyzes the activation of long-chain fatty acids as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase (PKS) for further chain extension.<ref>PMID:15042094</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Myctu]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Aldrich, C C]]
[[Category: Aldrich CC]]
[[Category: Anderson, W A]]
[[Category: Anderson WA]]
[[Category: Structural genomic]]
[[Category: Flores KJ]]
[[Category: Flores, K J]]
[[Category: Grimes KD]]
[[Category: Grimes, K D]]
[[Category: Kuhn ML]]
[[Category: Kuhn, M L]]
[[Category: Minasov G]]
[[Category: Minasov, G]]
[[Category: Shuvalova L]]
[[Category: Shuvalova, L]]
[[Category: Warwrzak Z]]
[[Category: Warwrzak, Z]]
[[Category: Wilson DJ]]
[[Category: Wilson, D J]]
[[Category: Csgid]]
[[Category: Fadd32]]
[[Category: Ligase-ligase inhibitor complex]]
[[Category: Long-chain-fatty-acid--amp ligase]]

Latest revision as of 10:46, 16 August 2023

2.25 Angstrom Resolution Crystal Structure of Long-chain-fatty-acid-AMP Ligase FadD32 from Mycobacterium tuberculosis in complex with Inhibitor 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine

5hm3, resolution 2.25Å

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