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<StructureSection load='5hyp' size='340' side='right'caption='[[5hyp]], [[Resolution|resolution]] 3.02&Aring;' scene=''>
<StructureSection load='5hyp' size='340' side='right'caption='[[5hyp]], [[Resolution|resolution]] 3.02&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5hyp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HYP FirstGlance]. <br>
<table><tr><td colspan='2'>[[5hyp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HYP FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hyu|5hyu]], [[5hyt|5hyt]], [[5hzp|5hzp]], [[5i0q|5i0q]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.024&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C4BPA, C4BP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), emm28 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1314 "Micrococcus scarlatinae" Klein 1884])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyp OCA], [https://pdbe.org/5hyp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hyp RCSB], [https://www.ebi.ac.uk/pdbsum/5hyp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyp ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyp OCA], [http://pdbe.org/5hyp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hyp RCSB], [http://www.ebi.ac.uk/pdbsum/5hyp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN]] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.  
[https://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Micrococcus scarlatinae klein 1884]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bahn-Suh, A J]]
[[Category: Streptococcus pyogenes]]
[[Category: Buffalo, C Z]]
[[Category: Bahn-Suh AJ]]
[[Category: Ghosh, P]]
[[Category: Buffalo CZ]]
[[Category: Complement]]
[[Category: Ghosh P]]
[[Category: Hypervariable antigen]]
[[Category: Immune system]]
[[Category: M protein]]
[[Category: Streptococcus pyogene]]
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