5hzi: Difference between revisions
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<StructureSection load='5hzi' size='340' side='right'caption='[[5hzi]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='5hzi' size='340' side='right'caption='[[5hzi]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5hzi]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5hzi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Avena_sativa Avena sativa] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HZI FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hzi OCA], [https://pdbe.org/5hzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hzi RCSB], [https://www.ebi.ac.uk/pdbsum/5hzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hzi ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref> [https://www.uniprot.org/uniprot/O49003_AVESA O49003_AVESA] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Avena sativa]] | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chu | [[Category: Chu PH]] | ||
[[Category: Dagliyan | [[Category: Dagliyan O]] | ||
[[Category: Dokholyan | [[Category: Dokholyan NV]] | ||
[[Category: Hahn | [[Category: Hahn KM]] | ||
[[Category: Schlichting | [[Category: Schlichting I]] | ||
[[Category: Shirvanyants | [[Category: Shirvanyants D]] | ||
[[Category: Tarnawski | [[Category: Tarnawski M]] | ||
Latest revision as of 11:01, 16 August 2023
Crystal structure of photoinhibitable Intersectin1 containing C450M mutant LOV2 domain
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