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'''Catalytic domain of the Adeno Associated Virus type 5 Rep protein''' | '''Catalytic domain of the Adeno Associated Virus type 5 Rep protein''' | ||
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[[Category: Kotin, R M.]] | [[Category: Kotin, R M.]] | ||
[[Category: Ronning, D R.]] | [[Category: Ronning, D R.]] | ||
[[Category: | [[Category: Adeno-associated virus]] | ||
[[Category: | [[Category: Endonuclease]] | ||
[[Category: | [[Category: Rep]] | ||
[[Category: | [[Category: Rolling circle replication]] | ||
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Revision as of 21:38, 2 May 2008
Catalytic domain of the Adeno Associated Virus type 5 Rep protein
Overview
Adeno-associated virus (AAV), unique among animal viruses in its ability to integrate into a specific chromosomal location, is a promising vector for human gene therapy. AAV Replication (Rep) protein is essential for viral replication and integration, and its amino terminal domain possesses site-specific DNA binding and endonuclease activities required for replication initiation and integration. This domain displays a novel endonuclease fold and demonstrates an unexpected structural relationship to other viral origin binding proteins such as the papillomavirus E1 protein and the SV40 T antigen. The active site, located at the bottom of a positively charged cleft, is formed by the spatial convergence of a divalent metal ion and two conserved sequence motifs that define the rolling circle replication superfamily.
About this Structure
1M55 is a Single protein structure of sequence from Adeno-associated virus - 5. Full crystallographic information is available from OCA.
Reference
Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep., Hickman AB, Ronning DR, Kotin RM, Dyda F, Mol Cell. 2002 Aug;10(2):327-37. PMID:12191478 Page seeded by OCA on Sat May 3 00:38:39 2008
