8prx: Difference between revisions
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==Crystal structure of human cathepsin L after reaction with the bound ketoamide inhibitor 13b== | |||
<StructureSection load='8prx' size='340' side='right'caption='[[8prx]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8prx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PRX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PRX FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=KH0:~{tert}-butyl+~{N}-[1-[(2~{S})-3-cyclopropyl-1-oxidanylidene-1-[[(2~{S},3~{S})-3-oxidanyl-4-oxidanylidene-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-2-oxidanylidene-pyridin-3-yl]carbamate'>KH0</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8prx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8prx OCA], [https://pdbe.org/8prx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8prx RCSB], [https://www.ebi.ac.uk/pdbsum/8prx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8prx ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Ewert | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN] Important for the overall degradation of proteins in lysosomes. | ||
[[Category: | __TOC__ | ||
[[Category: Karnicar | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Chapman HN]] | ||
[[Category: Meents | [[Category: Ewert W]] | ||
[[Category: | [[Category: Falke S]] | ||
[[Category: | [[Category: Guenther S]] | ||
[[Category: | [[Category: Hinrichs W]] | ||
[[Category: | [[Category: Karnicar K]] | ||
[[Category: Lieske J]] | |||
[[Category: Lindic N]] | |||
[[Category: Loboda J]] | |||
[[Category: Meents A]] | |||
[[Category: Reinke PYA]] | |||
[[Category: Sekirnik A]] | |||
[[Category: Turk D]] | |||
[[Category: Usenik A]] | |||
Revision as of 05:55, 23 August 2023
Crystal structure of human cathepsin L after reaction with the bound ketoamide inhibitor 13b
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