8puc: Difference between revisions
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==Structure of immature HTLV-1 CA-NTD from in vitro assembled MA126-CANC tubes: axis angle 05 degrees== | |||
<StructureSection load='8puc' size='340' side='right'caption='[[8puc]], [[Resolution|resolution]] 4.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8puc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_T-cell_leukemia_virus_type_I Human T-cell leukemia virus type I]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PUC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PUC FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.3Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8puc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8puc OCA], [https://pdbe.org/8puc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8puc RCSB], [https://www.ebi.ac.uk/pdbsum/8puc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8puc ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/X5GX59_9DELA X5GX59_9DELA] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Human T-cell leukemia virus type 1 (HTLV-1) has an atypical immature particle morphology compared to other retroviruses. This indicates that these particles are formed in a way that is unique. Here we report the results of cryo-electron tomography (cryo-ET) studies of HTLV-1 virus-like particles (VLPs) assembled in vitro , as well as derived from cells. This work shows that HTLV-1 employs an unconventional mechanism of Gag-Gag interactions to form the immature viral lattice. Analysis of high-resolution structural information from immature CA tubular arrays reveals that the primary stabilizing component in HTLV-1 is CA-NTD. Mutagenesis and biophysical analysis support this observation. This distinguishes HTLV-1 from other retroviruses, in which the stabilization is provided primarily by the CA-CTD. These results are the first to provide structural details of the quaternary arrangement of Gag for an immature deltaretrovirus, and this helps explain why HTLV-1 particles are morphologically distinct. | |||
Unconventional stabilization of the human T-cell leukemia virus type 1 immature Gag lattice.,Obr M, Percipalle M, Chernikova D, Yang H, Thader A, Pinke G, Porley D, Mansky LM, Dick RA, Schur FK bioRxiv. 2023 Jul 24:2023.07.24.548988. doi: 10.1101/2023.07.24.548988. Preprint. PMID:37546793<ref>PMID:37546793</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Chernikova | <div class="pdbe-citations 8puc" style="background-color:#fffaf0;"></div> | ||
[[Category: Dick | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Human T-cell leukemia virus type I]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Schur | [[Category: Chernikova D]] | ||
[[Category: | [[Category: Dick RA]] | ||
[[Category: | [[Category: Mansky LM]] | ||
[[Category: Obr M]] | |||
[[Category: Percipalle M]] | |||
[[Category: Pinke G]] | |||
[[Category: Porley D]] | |||
[[Category: Schur FKM]] | |||
[[Category: Thader A]] | |||
[[Category: Yang H]] | |||
