1s1e: Difference between revisions

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<StructureSection load='1s1e' size='340' side='right'caption='[[1s1e]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='1s1e' size='340' side='right'caption='[[1s1e]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1s1e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1E OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1S1E FirstGlance]. <br>
<table><tr><td colspan='2'>[[1s1e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S1E FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KCNIP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1s1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s1e OCA], [http://pdbe.org/1s1e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1s1e RCSB], [http://www.ebi.ac.uk/pdbsum/1s1e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1s1e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s1e OCA], [https://pdbe.org/1s1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s1e RCSB], [https://www.ebi.ac.uk/pdbsum/1s1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s1e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KCIP1_HUMAN KCIP1_HUMAN]] Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface.<ref>PMID:10676964</ref> <ref>PMID:11423117</ref> <ref>PMID:12829703</ref>
[https://www.uniprot.org/uniprot/KCIP1_HUMAN KCIP1_HUMAN] Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface.<ref>PMID:10676964</ref> <ref>PMID:11423117</ref> <ref>PMID:12829703</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bowlby, M R]]
[[Category: Bowlby MR]]
[[Category: Carroll, K C]]
[[Category: Carroll KC]]
[[Category: Chanda, P]]
[[Category: Chanda P]]
[[Category: Edris, W]]
[[Category: Edris W]]
[[Category: Jow, F]]
[[Category: Jow F]]
[[Category: Katz, A H]]
[[Category: Katz AH]]
[[Category: Kopsco, D C]]
[[Category: Kopsco DC]]
[[Category: Lin, L]]
[[Category: Lin L]]
[[Category: Lu, Q]]
[[Category: Lu Q]]
[[Category: Malakian, K]]
[[Category: Malakian K]]
[[Category: Megules, J]]
[[Category: Megules J]]
[[Category: Mosyak, L]]
[[Category: Mosyak L]]
[[Category: Olland, S]]
[[Category: Olland S]]
[[Category: Rhodes, K J]]
[[Category: Rhodes KJ]]
[[Category: Scannevin, R H]]
[[Category: Scannevin RH]]
[[Category: Somers, W]]
[[Category: Somers W]]
[[Category: Stahl, M]]
[[Category: Stahl M]]
[[Category: Taylor, M]]
[[Category: Taylor M]]
[[Category: Wang, K W]]
[[Category: Wang K-W]]
[[Category: Xu, W X]]
[[Category: Xu W-X]]
[[Category: Xu, Z B]]
[[Category: Xu Z-B]]
[[Category: Calcium-binding protein]]
[[Category: Ef-finger]]
[[Category: Kchip]]
[[Category: Kv channel-interacting protein]]
[[Category: Transport protein]]
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