1t32: Difference between revisions

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<StructureSection load='1t32' size='340' side='right'caption='[[1t32]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='1t32' size='340' side='right'caption='[[1t32]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1t32]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T32 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1T32 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1t32]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T32 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OHH:2-[3-({METHYL[1-(2-NAPHTHOYL)PIPERIDIN-4-YL]AMINO}CARBONYL)-2-NAPHTHYL]-1-(1-NAPHTHYL)-2-OXOETHYLPHOSPHONIC+ACID'>OHH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1cgh|1cgh]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OHH:2-[3-({METHYL[1-(2-NAPHTHOYL)PIPERIDIN-4-YL]AMINO}CARBONYL)-2-NAPHTHYL]-1-(1-NAPHTHYL)-2-OXOETHYLPHOSPHONIC+ACID'>OHH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HUMAN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t32 OCA], [https://pdbe.org/1t32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t32 RCSB], [https://www.ebi.ac.uk/pdbsum/1t32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t32 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_G Cathepsin G], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.20 3.4.21.20] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1t32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t32 OCA], [http://pdbe.org/1t32 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t32 RCSB], [http://www.ebi.ac.uk/pdbsum/1t32 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t32 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CATG_HUMAN CATG_HUMAN]] Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.<ref>PMID:8194606</ref> <ref>PMID:1861080</ref> <ref>PMID:1937776</ref>
[https://www.uniprot.org/uniprot/CATG_HUMAN CATG_HUMAN] Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.<ref>PMID:8194606</ref> <ref>PMID:1861080</ref> <ref>PMID:1937776</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cathepsin G]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Abraham, W M]]
[[Category: Abraham WM]]
[[Category: Andrade-Gordon, P]]
[[Category: Andrade-Gordon P]]
[[Category: Cera, E Di]]
[[Category: Chen Z]]
[[Category: Chen, Z]]
[[Category: Corcoran TW]]
[[Category: Corcoran, T W]]
[[Category: Damiano BP]]
[[Category: Damiano, B P]]
[[Category: Derian CK]]
[[Category: Derian, C K]]
[[Category: Di Cera E]]
[[Category: Eckardt, A J]]
[[Category: Eckardt AJ]]
[[Category: Garavilla, L de]]
[[Category: Giardino EC]]
[[Category: Giardino, E C]]
[[Category: Greco MN]]
[[Category: Greco, M N]]
[[Category: Haertlein BJ]]
[[Category: Haertlein, B J]]
[[Category: Kauffman JA]]
[[Category: Kauffman, J A]]
[[Category: Maryanoff BE]]
[[Category: Maryanoff, B E]]
[[Category: Mathews FS]]
[[Category: Mathews, F S]]
[[Category: Pineda AO]]
[[Category: Pineda, A O]]
[[Category: Sukumar N]]
[[Category: Sukumar, N]]
[[Category: Wells GI]]
[[Category: Wells, G I]]
[[Category: De Garavilla L]]
[[Category: Hydrolase]]
[[Category: Inflammation inhibitor serine protease]]
Retrieved from "https://proteopedia.org/1t32"