1u27: Difference between revisions

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<StructureSection load='1u27' size='340' side='right'caption='[[1u27]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='1u27' size='340' side='right'caption='[[1u27]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1u27]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U27 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1U27 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1u27]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U27 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4IP:INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE'>4IP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Pscd2, Sec7b ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4IP:INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE'>4IP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1u27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u27 OCA], [http://pdbe.org/1u27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u27 RCSB], [http://www.ebi.ac.uk/pdbsum/1u27 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u27 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u27 OCA], [https://pdbe.org/1u27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u27 RCSB], [https://www.ebi.ac.uk/pdbsum/1u27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u27 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CYH2_MOUSE CYH2_MOUSE]] Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane.<ref>PMID:18042453</ref>
[https://www.uniprot.org/uniprot/CYH2_MOUSE CYH2_MOUSE] Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane.<ref>PMID:18042453</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Cronin, T C]]
[[Category: Cronin TC]]
[[Category: Czech, M P]]
[[Category: Czech MP]]
[[Category: DiNitto, J P]]
[[Category: DiNitto JP]]
[[Category: Lambright, D G]]
[[Category: Lambright DG]]
[[Category: Lipid binding]]
[[Category: Lipid binding protein]]
[[Category: Phosphoinositide]]
[[Category: Pleckstrin homology domain]]
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