1z8d: Difference between revisions

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<StructureSection load='1z8d' size='340' side='right'caption='[[1z8d]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='1z8d' size='340' side='right'caption='[[1z8d]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1z8d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z8D FirstGlance]. <br>
<table><tr><td colspan='2'>[[1z8d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z8D FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2gpa|2gpa]], [[7gpb|7gpb]], [[3amv|3amv]], [[1fa9|1fa9]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PYGM ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z8d OCA], [https://pdbe.org/1z8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z8d RCSB], [https://www.ebi.ac.uk/pdbsum/1z8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z8d ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z8d OCA], [https://pdbe.org/1z8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z8d RCSB], [https://www.ebi.ac.uk/pdbsum/1z8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z8d ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/PYGM_HUMAN PYGM_HUMAN]] Defects in PYGM are the cause of glycogen storage disease type 5 (GSD5) [MIM:[https://omim.org/entry/232600 232600]]; also known as McArdle disease. GSD5 is a metabolic disorder resulting in myopathy characterized by exercise intolerance, cramps, muscle weakness and recurrent myoglobinuria.<ref>PMID:8316268</ref> <ref>PMID:8535454</ref> <ref>PMID:7603523</ref> <ref>PMID:9506549</ref> <ref>PMID:10417800</ref> <ref>PMID:10382911</ref> <ref>PMID:10382912</ref> <ref>PMID:10681080</ref> <ref>PMID:10590419</ref> <ref>PMID:10714589</ref> <ref>PMID:10899452</ref> <ref>PMID:11706962</ref> <ref>PMID:12031624</ref>
[https://www.uniprot.org/uniprot/PYGM_HUMAN PYGM_HUMAN] Defects in PYGM are the cause of glycogen storage disease type 5 (GSD5) [MIM:[https://omim.org/entry/232600 232600]; also known as McArdle disease. GSD5 is a metabolic disorder resulting in myopathy characterized by exercise intolerance, cramps, muscle weakness and recurrent myoglobinuria.<ref>PMID:8316268</ref> <ref>PMID:8535454</ref> <ref>PMID:7603523</ref> <ref>PMID:9506549</ref> <ref>PMID:10417800</ref> <ref>PMID:10382911</ref> <ref>PMID:10382912</ref> <ref>PMID:10681080</ref> <ref>PMID:10590419</ref> <ref>PMID:10714589</ref> <ref>PMID:10899452</ref> <ref>PMID:11706962</ref> <ref>PMID:12031624</ref>  
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/PYGM_HUMAN PYGM_HUMAN]] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.  
[https://www.uniprot.org/uniprot/PYGM_HUMAN PYGM_HUMAN] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Phosphorylase]]
[[Category: Crowther RL]]
[[Category: Crowther, R L]]
[[Category: Hong LN]]
[[Category: Hong, L N]]
[[Category: Kammlott RU]]
[[Category: Kammlott, R U]]
[[Category: Levin W]]
[[Category: Levin, W]]
[[Category: Li S]]
[[Category: Li, S]]
[[Category: Liu CM]]
[[Category: Liu, C M]]
[[Category: Lucas-McGady D]]
[[Category: Lucas-McGady, D]]
[[Category: Lukacs CM]]
[[Category: Lukacs, C M]]
[[Category: Oikonomakos NG]]
[[Category: Oikonomakos, N G]]
[[Category: Pietranico S]]
[[Category: Pietranico, S]]
[[Category: Reik L]]
[[Category: Reik, L]]
[[Category: Transferase]]
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