2a2k: Difference between revisions

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<StructureSection load='2a2k' size='340' side='right'caption='[[2a2k]], [[Resolution|resolution]] 1.52&Aring;' scene=''>
<StructureSection load='2a2k' size='340' side='right'caption='[[2a2k]], [[Resolution|resolution]] 1.52&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2a2k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A2K FirstGlance]. <br>
<table><tr><td colspan='2'>[[2a2k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A2K FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.52&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qb0|1qb0]], [[1ymk|1ymk]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDC25B, CDC25HU2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2k OCA], [https://pdbe.org/2a2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a2k RCSB], [https://www.ebi.ac.uk/pdbsum/2a2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a2k ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2k OCA], [https://pdbe.org/2a2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a2k RCSB], [https://www.ebi.ac.uk/pdbsum/2a2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a2k ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/MPIP2_HUMAN MPIP2_HUMAN]] Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.<ref>PMID:17332740</ref>
[https://www.uniprot.org/uniprot/MPIP2_HUMAN MPIP2_HUMAN] Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.<ref>PMID:17332740</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Brown P]]
[[Category: Brown, P]]
[[Category: Buhrman G]]
[[Category: Buhrman, G]]
[[Category: Edelsbrunner H]]
[[Category: Edelsbrunner, H]]
[[Category: Kristjansdottir K]]
[[Category: Kristjansdottir, K]]
[[Category: Parks J]]
[[Category: Parks, J]]
[[Category: Rudolph J]]
[[Category: Rudolph, J]]
[[Category: Safi A]]
[[Category: Safi, A]]
[[Category: Sohn J]]
[[Category: Sohn, J]]
[[Category: Yang W]]
[[Category: Yang, W]]
[[Category: Active site mutant]]
[[Category: Dual specificity]]
[[Category: Hydrolase]]
[[Category: Phosphatase]]
[[Category: Substrate trapping]]
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