2ahs: Difference between revisions

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<StructureSection load='2ahs' size='340' side='right'caption='[[2ahs]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='2ahs' size='340' side='right'caption='[[2ahs]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ahs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AHS FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ahs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AHS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1rpm|1rpm]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPRB, PTPB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ahs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ahs OCA], [https://pdbe.org/2ahs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ahs RCSB], [https://www.ebi.ac.uk/pdbsum/2ahs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ahs ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ahs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ahs OCA], [https://pdbe.org/2ahs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ahs RCSB], [https://www.ebi.ac.uk/pdbsum/2ahs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ahs ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/PTPRB_HUMAN PTPRB_HUMAN]] Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).<ref>PMID:19116766</ref> <ref>PMID:19136612</ref>
[https://www.uniprot.org/uniprot/PTPRB_HUMAN PTPRB_HUMAN] Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).<ref>PMID:19116766</ref> <ref>PMID:19136612</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Arrowsmith C]]
[[Category: Arrowsmith, C]]
[[Category: Ball L]]
[[Category: Ball, L]]
[[Category: Barr A]]
[[Category: Barr, A]]
[[Category: Bray J]]
[[Category: Bray, J]]
[[Category: Bunkoczi G]]
[[Category: Bunkoczi, G]]
[[Category: Burgess N]]
[[Category: Burgess, N]]
[[Category: Das S]]
[[Category: Das, S]]
[[Category: Debreczeni J]]
[[Category: Debreczeni, J]]
[[Category: Edwards A]]
[[Category: Delft, F von]]
[[Category: Eswaran J]]
[[Category: Edwards, A]]
[[Category: Gileadi O]]
[[Category: Eswaran, J]]
[[Category: Knapp S]]
[[Category: Gileadi, O]]
[[Category: Sobott F]]
[[Category: Knapp, S]]
[[Category: Sundstrom M]]
[[Category: Structural genomic]]
[[Category: Turnbull A]]
[[Category: Sobott, F]]
[[Category: Ugochukwu E]]
[[Category: Sundstrom, M]]
[[Category: Weigelt J]]
[[Category: Turnbull, A]]
[[Category: Von Delft F]]
[[Category: Ugochukwu, E]]
[[Category: Weigelt, J]]
[[Category: Beta]]
[[Category: Hydrolase]]
[[Category: Sgc]]
[[Category: Tyrosine receptor phosphatase]]
Retrieved from "https://proteopedia.org/2ahs"