2bdm: Difference between revisions

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<StructureSection load='2bdm' size='340' side='right'caption='[[2bdm]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='2bdm' size='340' side='right'caption='[[2bdm]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2bdm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BDM FirstGlance]. <br>
<table><tr><td colspan='2'>[[2bdm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BDM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TMI:1-[PHENYL-(4-PHENYLPHENYL)-METHYL]IMIDAZOLE'>TMI</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1suo|1suo]], [[1po5|1po5]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TMI:1-[PHENYL-(4-PHENYLPHENYL)-METHYL]IMIDAZOLE'>TMI</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP2B4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bdm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bdm OCA], [https://pdbe.org/2bdm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bdm RCSB], [https://www.ebi.ac.uk/pdbsum/2bdm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bdm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bdm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bdm OCA], [https://pdbe.org/2bdm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bdm RCSB], [https://www.ebi.ac.uk/pdbsum/2bdm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bdm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CP2B4_RABIT CP2B4_RABIT]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it has a unique preference for the 5,6-olefin.  
[https://www.uniprot.org/uniprot/CP2B4_RABIT CP2B4_RABIT] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it has a unique preference for the 5,6-olefin.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: European rabbit]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Unspecific monooxygenase]]
[[Category: Oryctolagus cuniculus]]
[[Category: Halpert, J R]]
[[Category: Halpert JR]]
[[Category: Muralidhara, B K]]
[[Category: Muralidhara BK]]
[[Category: Stout, C D]]
[[Category: Stout CD]]
[[Category: Sun, L]]
[[Category: Sun L]]
[[Category: White, M A]]
[[Category: White MA]]
[[Category: Zhao, Y]]
[[Category: Zhao Y]]
[[Category: Cyp 2b4]]
[[Category: Cyp lm2]]
[[Category: Membrane protein]]
[[Category: Monooxygenase]]
[[Category: Oxidoreductase]]
[[Category: P450]]
Retrieved from "https://proteopedia.org/2bdm"