2f7m: Difference between revisions

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<StructureSection load='2f7m' size='340' side='right'caption='[[2f7m]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='2f7m' size='340' side='right'caption='[[2f7m]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2f7m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F7M FirstGlance]. <br>
<table><tr><td colspan='2'>[[2f7m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F7M FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2f89|2f89]], [[2f8c|2f8c]], [[2f8z|2f8z]], [[2f92|2f92]], [[2f94|2f94]], [[2f9k|2f9k]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f7m OCA], [https://pdbe.org/2f7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f7m RCSB], [https://www.ebi.ac.uk/pdbsum/2f7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f7m ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f7m OCA], [https://pdbe.org/2f7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f7m RCSB], [https://www.ebi.ac.uk/pdbsum/2f7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f7m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.  
[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bitsch, F]]
[[Category: Bitsch F]]
[[Category: Bourgier, E]]
[[Category: Bourgier E]]
[[Category: Geiser, M]]
[[Category: Geiser M]]
[[Category: Green, J R]]
[[Category: Green JR]]
[[Category: Hemmig, R]]
[[Category: Hemmig R]]
[[Category: Jahnke, W]]
[[Category: Jahnke W]]
[[Category: Kroemer, M]]
[[Category: Kroemer M]]
[[Category: Lehmann, S]]
[[Category: Lehmann S]]
[[Category: Ramage, P]]
[[Category: Ramage P]]
[[Category: Rieffel, S]]
[[Category: Rieffel S]]
[[Category: Rondeau, J M]]
[[Category: Rondeau J-M]]
[[Category: Strauss, A]]
[[Category: Strauss A]]
[[Category: Cholesterol biosynthesis]]
[[Category: Isoprene biosynthesis]]
[[Category: Transferase]]
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