5i3o: Difference between revisions

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<StructureSection load='5i3o' size='340' side='right'caption='[[5i3o]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='5i3o' size='340' side='right'caption='[[5i3o]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5i3o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I3O FirstGlance]. <br>
<table><tr><td colspan='2'>[[5i3o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5I3O FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IDV:N-(6-{3-[(DIMETHYLSULFAMOYL)AMINO]PHENYL}-1H-INDAZOL-3-YL)CYCLOPROPANECARBOXAMIDE'>IDV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4w9w|4w9w]], [[4w9x|4w9x]], [[5i3r|5i3r]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IDV:N-(6-{3-[(DIMETHYLSULFAMOYL)AMINO]PHENYL}-1H-INDAZOL-3-YL)CYCLOPROPANECARBOXAMIDE'>IDV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BMP2K, BIKE, HRIHFB2017 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5i3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i3o OCA], [https://pdbe.org/5i3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5i3o RCSB], [https://www.ebi.ac.uk/pdbsum/5i3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5i3o ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i3o OCA], [http://pdbe.org/5i3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i3o RCSB], [http://www.ebi.ac.uk/pdbsum/5i3o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i3o ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BMP2K_HUMAN BMP2K_HUMAN]] May be involved in osteoblast differentiation.  
[https://www.uniprot.org/uniprot/BMP2K_HUMAN BMP2K_HUMAN] May be involved in osteoblast differentiation.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C H]]
[[Category: Arruda P]]
[[Category: Arruda, P]]
[[Category: Axtman A]]
[[Category: Axtman, A]]
[[Category: Bountra C]]
[[Category: Bountra, C]]
[[Category: Counago RM]]
[[Category: Counago, R M]]
[[Category: Drewry D]]
[[Category: Drewry, D]]
[[Category: Edwards AM]]
[[Category: Edwards, A M]]
[[Category: Elkins JM]]
[[Category: Elkins, J M]]
[[Category: Gileadi O]]
[[Category: Gileadi, O]]
[[Category: Krojer T]]
[[Category: Krojer, T]]
[[Category: Savitsky P]]
[[Category: Structural genomic]]
[[Category: Sorrell FJ]]
[[Category: Savitsky, P]]
[[Category: Wells C]]
[[Category: Sorrell, F J]]
[[Category: Willson TM]]
[[Category: Wells, C]]
[[Category: Zhang C]]
[[Category: Willson, T M]]
[[Category: Zuercher W]]
[[Category: Zhang, C]]
[[Category: Zuercher, W]]
[[Category: Protein kinase domain]]
[[Category: Sgc]]
[[Category: Transferase]]
[[Category: Transferase-transferase inhibitor complex]]

Latest revision as of 08:22, 23 August 2023

Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor

5i3o, resolution 2.40Å

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