8g04: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8g04 is ~~ON HOLD until 2025~~-01-31

==Signaling thrombopoietin-receptor complex==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8g04]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G04 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8G04 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8g04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g04 OCA], [https://pdbe.org/8g04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g04 RCSB], [https://www.ebi.ac.uk/pdbsum/8g04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g04 ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/TPO_HUMAN TPO_HUMAN] Defects in THPO are the cause of thrombocythemia type 1 (THCYT1) [MIM:[https://omim.org/entry/187950 187950]. A myeloproliferative disorder characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications.<ref>PMID:9425899</ref>

== Function ==

[https://www.uniprot.org/uniprot/TPO_HUMAN TPO_HUMAN] Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Garcia KC]]

[[Category: Gati C]]

[[Category: Jude KM]]

[[Category: Tsutsumi N]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8g04 is ON HOLD  until 2025-01-31
+==Signaling thrombopoietin-receptor complex==
+<StructureSection load='8g04' size='340' side='right'caption='[[8g04]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8g04]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G04 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g04 OCA], [https://pdbe.org/8g04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g04 RCSB], [https://www.ebi.ac.uk/pdbsum/8g04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g04 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/TPO_HUMAN TPO_HUMAN] Defects in THPO are the cause of thrombocythemia type 1 (THCYT1) [MIM:[https://omim.org/entry/187950 187950]. A myeloproliferative disorder characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications.<ref>PMID:9425899</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/TPO_HUMAN TPO_HUMAN] Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Garcia KC]]
+[[Category: Gati C]]
+[[Category: Jude KM]]
+[[Category: Tsutsumi N]]