2gpv: Difference between revisions

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<StructureSection load='2gpv' size='340' side='right'caption='[[2gpv]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
<StructureSection load='2gpv' size='340' side='right'caption='[[2gpv]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2gpv]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GPV FirstGlance]. <br>
<table><tr><td colspan='2'>[[2gpv]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GPV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OHT:4-HYDROXYTAMOXIFEN'>OHT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2gp7|2gp7]], [[2gpo|2gpo]], [[2gpp|2gpp]], [[2gpu|2gpu]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OHT:4-HYDROXYTAMOXIFEN'>OHT</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ESRRG ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gpv OCA], [https://pdbe.org/2gpv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gpv RCSB], [https://www.ebi.ac.uk/pdbsum/2gpv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gpv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gpv OCA], [https://pdbe.org/2gpv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gpv RCSB], [https://www.ebi.ac.uk/pdbsum/2gpv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gpv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ERR3_HUMAN ERR3_HUMAN]] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).<ref>PMID:19067653</ref> <ref>PMID:18063693</ref> <ref>PMID:11864604</ref> [[https://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN]] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
[https://www.uniprot.org/uniprot/ERR3_HUMAN ERR3_HUMAN] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).<ref>PMID:19067653</ref> <ref>PMID:18063693</ref> <ref>PMID:11864604</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Consler, T G]]
[[Category: Consler TG]]
[[Category: Lambert, M H]]
[[Category: Lambert MH]]
[[Category: McKee, D D]]
[[Category: McKee DD]]
[[Category: Miller, A B]]
[[Category: Miller AB]]
[[Category: Nolte, R T]]
[[Category: Nolte RT]]
[[Category: Osband-miller, L A]]
[[Category: Osband-miller LA]]
[[Category: Wang, L]]
[[Category: Wang L]]
[[Category: Willson, T M]]
[[Category: Willson TM]]
[[Category: Zuercher, W J]]
[[Category: Zuercher WJ]]
[[Category: Err]]
[[Category: Errg]]
[[Category: Esrrg]]
[[Category: Estrogen related receptor]]
[[Category: Nuclear receptor]]
[[Category: Smrt]]
[[Category: Steroid receptor]]
[[Category: Tamoxifen]]
[[Category: Transcription]]
Retrieved from "https://proteopedia.org/2gpv"