2h4u: Difference between revisions
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<StructureSection load='2h4u' size='340' side='right'caption='[[2h4u]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='2h4u' size='340' side='right'caption='[[2h4u]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2h4u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2h4u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H4U FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h4u OCA], [https://pdbe.org/2h4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h4u RCSB], [https://www.ebi.ac.uk/pdbsum/2h4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h4u ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h4u OCA], [https://pdbe.org/2h4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h4u RCSB], [https://www.ebi.ac.uk/pdbsum/2h4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h4u ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/ACO13_HUMAN ACO13_HUMAN] Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith C]] | ||
[[Category: Berglund | [[Category: Berglund H]] | ||
[[Category: Edwards | [[Category: Edwards A]] | ||
[[Category: Ehn | [[Category: Ehn M]] | ||
[[Category: Flodin | [[Category: Flodin S]] | ||
[[Category: Grasslund | [[Category: Grasslund S]] | ||
[[Category: Hallberg | [[Category: Hallberg M]] | ||
[[Category: Hammerstrom | [[Category: Hammerstrom M]] | ||
[[Category: Hogbom | [[Category: Hogbom M]] | ||
[[Category: Holmberg-Schiavone | [[Category: Holmberg-Schiavone L]] | ||
[[Category: Kotenyova | [[Category: Kotenyova T]] | ||
[[Category: Nilsson-Ehle | [[Category: Nilsson-Ehle P]] | ||
[[Category: Nordlund | [[Category: Nordlund P]] | ||
[[Category: Nyman | [[Category: Nyman T]] | ||
[[Category: Ogg | [[Category: Ogg DJ]] | ||
[[Category: Persson | [[Category: Persson C]] | ||
[[Category: Sagemark J]] | |||
[[Category: Sagemark | [[Category: Sundstrom M]] | ||
[[Category: Sundstrom | [[Category: Thorsell A-G]] | ||
[[Category: Thorsell | [[Category: Uppenberg J]] | ||
[[Category: Uppenberg | [[Category: Weigelt J]] | ||
[[Category: Weigelt | |||
Latest revision as of 09:52, 30 August 2023
Crystal Structure of Human Thioesterase Superfamily Member 2 (CASP Target)
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