2i61: Difference between revisions

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<StructureSection load='2i61' size='340' side='right'caption='[[2i61]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
<StructureSection load='2i61' size='340' side='right'caption='[[2i61]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2i61]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leiqh Leiqh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I61 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2i61]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leiurus_quinquestriatus_hebraeus Leiurus quinquestriatus hebraeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I61 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CO2:CARBON+DIOXIDE'>CO2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CO2:CARBON+DIOXIDE'>CO2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i61 OCA], [https://pdbe.org/2i61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i61 RCSB], [https://www.ebi.ac.uk/pdbsum/2i61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i61 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i61 OCA], [https://pdbe.org/2i61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i61 RCSB], [https://www.ebi.ac.uk/pdbsum/2i61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i61 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/SIX2_LEIQH SIX2_LEIQH]] Depressant insect beta-toxins cause a transient contraction paralysis followed by a slow flaccid paralysis. They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active only on insects.<ref>PMID:9275012</ref>
[https://www.uniprot.org/uniprot/SIX2_LEIHE SIX2_LEIHE] Depressant insect beta-toxins cause a transient contraction paralysis followed by a slow flaccid paralysis. They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active only on insects.<ref>PMID:9275012</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Leiqh]]
[[Category: Leiurus quinquestriatus hebraeus]]
[[Category: Frolow, F]]
[[Category: Frolow F]]
[[Category: Gordon, D]]
[[Category: Gordon D]]
[[Category: Gurevitz, M]]
[[Category: Gurevitz M]]
[[Category: Karbat, I]]
[[Category: Karbat I]]
[[Category: Turkov, M]]
[[Category: Turkov M]]
[[Category: Anti-insect]]
[[Category: Depressant]]
[[Category: Scorpion toxin]]
[[Category: Sodium channel modifer]]
[[Category: Toxin]]
Retrieved from "https://proteopedia.org/2i61"