2nnu: Difference between revisions

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<StructureSection load='2nnu' size='340' side='right'caption='[[2nnu]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
<StructureSection load='2nnu' size='340' side='right'caption='[[2nnu]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2nnu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hpv16 Hpv16] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NNU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NNU FirstGlance]. <br>
<table><tr><td colspan='2'>[[2nnu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NNU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NNU FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">E2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=333760 HPV16]), BRD4, HUNK1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nnu OCA], [https://pdbe.org/2nnu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nnu RCSB], [https://www.ebi.ac.uk/pdbsum/2nnu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nnu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nnu OCA], [https://pdbe.org/2nnu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nnu RCSB], [https://www.ebi.ac.uk/pdbsum/2nnu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nnu ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> 
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/VE2_HPV16 VE2_HPV16]] Plays an accessory role in initiation of DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.<ref>PMID:3033289</ref> <ref>PMID:1326651</ref> <ref>PMID:15681049</ref> [[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
[https://www.uniprot.org/uniprot/VE2_HPV16 VE2_HPV16] Plays an accessory role in initiation of DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.<ref>PMID:3033289</ref> <ref>PMID:1326651</ref> <ref>PMID:15681049</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hpv16]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Human papillomavirus type 16]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Abbate, E A]]
[[Category: Abbate EA]]
[[Category: Botchan, M R]]
[[Category: Botchan MR]]
[[Category: Voitenleitner, C]]
[[Category: Voitenleitner C]]
[[Category: Amphipathic helix]]
[[Category: Helical peptide]]
[[Category: Protein-peptide complex]]
[[Category: Three helix bundle]]
[[Category: Transcription]]
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