2ps4: Difference between revisions

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<StructureSection load='2ps4' size='340' side='right'caption='[[2ps4]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
<StructureSection load='2ps4' size='340' side='right'caption='[[2ps4]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ps4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fussp Fussp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PS4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PS4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ps4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusarium_sporotrichioides Fusarium sporotrichioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PS4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PS4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.46&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jfa|1jfa]], [[1yj4|1yj4]], [[1kiy|1kiy]], [[2aek|2aek]], [[2ps6|2ps6]], [[2ps5|2ps5]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRI5, TOX 5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5514 FUSSP])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Trichodiene_synthase Trichodiene synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.6 4.2.3.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ps4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ps4 OCA], [https://pdbe.org/2ps4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ps4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ps4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ps4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ps4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ps4 OCA], [https://pdbe.org/2ps4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ps4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ps4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ps4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TRI5_FUSSP TRI5_FUSSP]] TS is a member of the terpene cyclase group of enzymes. It catalyzes the isomerization and cyclization of farnesyl pyro-phosphate to form trichodiene, the first cyclic intermediate in the biosynthetic pathway for trichothecenes. It serves to branch trichothecene biosynthesis from the isoprenoid pathway.  
[https://www.uniprot.org/uniprot/TRI5_FUSSP TRI5_FUSSP] TS is a member of the terpene cyclase group of enzymes. It catalyzes the isomerization and cyclization of farnesyl pyro-phosphate to form trichodiene, the first cyclic intermediate in the biosynthetic pathway for trichothecenes. It serves to branch trichothecene biosynthesis from the isoprenoid pathway.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Fussp]]
[[Category: Fusarium sporotrichioides]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Trichodiene synthase]]
[[Category: Cane DE]]
[[Category: Cane, D E]]
[[Category: Christianson DW]]
[[Category: Christianson, D W]]
[[Category: Vedula LS]]
[[Category: Vedula, L S]]
[[Category: Ethylene glycol]]
[[Category: Lyase]]
[[Category: Magnesium]]
[[Category: Nse/dte motif]]
[[Category: Site-directed mutagenesis]]
[[Category: Terpenoid synthase fold]]
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