2ql2: Difference between revisions

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<StructureSection load='2ql2' size='340' side='right'caption='[[2ql2]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='2ql2' size='340' side='right'caption='[[2ql2]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ql2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QL2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ql2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QL2 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tcf3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Neurod1, Neurod ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ql2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ql2 OCA], [https://pdbe.org/2ql2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ql2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ql2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ql2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ql2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ql2 OCA], [https://pdbe.org/2ql2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ql2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ql2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ql2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/NDF1_MOUSE NDF1_MOUSE]] Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis.<ref>PMID:9308961</ref> <ref>PMID:9512516</ref> <ref>PMID:10398678</ref> <ref>PMID:10639171</ref> <ref>PMID:11152640</ref> <ref>PMID:11861467</ref> <ref>PMID:11970861</ref> <ref>PMID:12810726</ref> <ref>PMID:14697366</ref> <ref>PMID:15797719</ref> <ref>PMID:18007592</ref> <ref>PMID:18339630</ref> <ref>PMID:19200230</ref> <ref>PMID:19759004</ref> <ref>PMID:21593321</ref> 
[https://www.uniprot.org/uniprot/TFE2_MOUSE TFE2_MOUSE] Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (PubMed:15226298, PubMed:18214987). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (PubMed:18214987). Together with TCF15, required for the mesenchymal to epithelial transition (PubMed:11309385, PubMed:15226298). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (PubMed:15226298, PubMed:18214987, PubMed:30426815). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (By similarity). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (PubMed:2181401).[UniProtKB:P15923]<ref>PMID:11309385</ref> <ref>PMID:15226298</ref> <ref>PMID:18214987</ref> <ref>PMID:2181401</ref>   Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity.[UniProtKB:P15923]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Guanga, G P]]
[[Category: Guanga GP]]
[[Category: Longo, A]]
[[Category: Longo A]]
[[Category: Rose, R B]]
[[Category: Rose RB]]
[[Category: Activator]]
[[Category: Basic-helix-loop-helix]]
[[Category: Cytoplasm]]
[[Category: Developmental protein]]
[[Category: Differentiation]]
[[Category: Dna-binding]]
[[Category: Heterodimer]]
[[Category: Neurogenesis]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Phosphorylation]]
[[Category: Protein-dna complex]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription-dna complex]]
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