2qsz: Difference between revisions

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<StructureSection load='2qsz' size='340' side='right'caption='[[2qsz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='2qsz' size='340' side='right'caption='[[2qsz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2qsz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QSZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2qsz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QSZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2qsy|2qsy]], [[2qt0|2qt0]], [[2qt1|2qt1]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NRK1, C9orf95 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qsz OCA], [https://pdbe.org/2qsz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qsz RCSB], [https://www.ebi.ac.uk/pdbsum/2qsz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qsz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qsz OCA], [https://pdbe.org/2qsz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qsz RCSB], [https://www.ebi.ac.uk/pdbsum/2qsz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qsz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/NRK1_HUMAN NRK1_HUMAN]] Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine.<ref>PMID:15137942</ref>
[https://www.uniprot.org/uniprot/NRK1_HUMAN NRK1_HUMAN] Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine.<ref>PMID:15137942</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bochkarev, A]]
[[Category: Bochkarev A]]
[[Category: Brenner, C]]
[[Category: Brenner C]]
[[Category: Edwards, A M]]
[[Category: Edwards AM]]
[[Category: Landry, R]]
[[Category: Landry R]]
[[Category: Nedyalkova, L]]
[[Category: Nedyalkova L]]
[[Category: Park, H]]
[[Category: Park H]]
[[Category: Rabeh, W M]]
[[Category: Rabeh WM]]
[[Category: Structural genomic]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M]]
[[Category: Tempel W]]
[[Category: Tempel, W]]
[[Category: Weigelt J]]
[[Category: Weigelt, J]]
[[Category: Adp]]
[[Category: Alternative splicing]]
[[Category: Atp-binding]]
[[Category: Nad biosynthesis]]
[[Category: Nad+]]
[[Category: Nicotinamide riboside]]
[[Category: Nicotinamide riboside kinase activity]]
[[Category: Nicotinic acid riboside kinase activity]]
[[Category: Non-protein kinase]]
[[Category: Nrk1]]
[[Category: Nucleotide-binding]]
[[Category: Pyridine nucleotide biosynthesis]]
[[Category: Sgc]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/2qsz"