3c7l: Difference between revisions

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<StructureSection load='3c7l' size='340' side='right'caption='[[3c7l]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
<StructureSection load='3c7l' size='340' side='right'caption='[[3c7l]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3c7l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C7L FirstGlance]. <br>
<table><tr><td colspan='2'>[[3c7l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C7L FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3c7k|3c7k]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rgs16, Rgsr ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c7l OCA], [https://pdbe.org/3c7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c7l RCSB], [https://www.ebi.ac.uk/pdbsum/3c7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c7l ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c7l OCA], [https://pdbe.org/3c7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c7l RCSB], [https://www.ebi.ac.uk/pdbsum/3c7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c7l ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/RGS16_MOUSE RGS16_MOUSE]] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals.  
[https://www.uniprot.org/uniprot/RGS16_MOUSE RGS16_MOUSE] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Chen, C]]
[[Category: Chen C]]
[[Category: Kercher, M A]]
[[Category: Kercher MA]]
[[Category: Sigler, P B]]
[[Category: Sigler PB]]
[[Category: Simon, M I]]
[[Category: Simon MI]]
[[Category: Slep, K C]]
[[Category: Slep KC]]
[[Category: Wieland, T]]
[[Category: Wieland T]]
[[Category: Gap]]
[[Category: Gtpase activating protein]]
[[Category: Heterotrimeric g-protein]]
[[Category: Lipoprotein]]
[[Category: Palmitate]]
[[Category: Phosphoprotein]]
[[Category: Rg]]
[[Category: Rgs16]]
[[Category: Signal transduction inhibitor]]
[[Category: Signaling protein]]
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