3ca0: Difference between revisions

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<StructureSection load='3ca0' size='340' side='right'caption='[[3ca0]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='3ca0' size='340' side='right'caption='[[3ca0]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ca0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sambucus_nigra Sambucus nigra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CA0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3CA0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ca0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sambucus_nigra Sambucus nigra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CA0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3c9z|3c9z]], [[3ca1|3ca1]], [[3ca3|3ca3]], [[3ca4|3ca4]], [[3ca5|3ca5]], [[3ca6|3ca6]], [[3cah|3cah]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3ca0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ca0 OCA], [http://pdbe.org/3ca0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ca0 RCSB], [http://www.ebi.ac.uk/pdbsum/3ca0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ca0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ca0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ca0 OCA], [https://pdbe.org/3ca0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ca0 RCSB], [https://www.ebi.ac.uk/pdbsum/3ca0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ca0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NIGB_SAMNI NIGB_SAMNI]] Non-toxic type 2 RIP which strongly inhibits mammalian protein synthesis but does not affect plant nor bacterial protein synthesis. The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA.  The B chain is a galactose-specific lectin that facilitates the binding of nigrin b to the cell membrane that precedes endocytosis.  
[https://www.uniprot.org/uniprot/NIGB_SAMNI NIGB_SAMNI] Non-toxic type 2 RIP which strongly inhibits mammalian protein synthesis but does not affect plant nor bacterial protein synthesis. The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA.  The B chain is a galactose-specific lectin that facilitates the binding of nigrin b to the cell membrane that precedes endocytosis.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Sambucus nigra]]
[[Category: Sambucus nigra]]
[[Category: Guillet, V]]
[[Category: Guillet V]]
[[Category: Maveyraud, L]]
[[Category: Maveyraud L]]
[[Category: Mourey, L]]
[[Category: Mourey L]]
[[Category: Niwa, H]]
[[Category: Niwa H]]
[[Category: Palmer, R A]]
[[Category: Palmer RA]]
[[Category: Reynolds, C D]]
[[Category: Reynolds CD]]
[[Category: Beta-trefoil]]
[[Category: Glycoprotein]]
[[Category: Glycosylation]]
[[Category: Lectin]]
[[Category: Plant protein]]
[[Category: Ricin-b domain]]
[[Category: Sugar binding protein]]
Retrieved from "https://proteopedia.org/3ca0"