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| <StructureSection load='3dxk' size='340' side='right'caption='[[3dxk]], [[Resolution|resolution]] 2.70Å' scene=''> | | <StructureSection load='3dxk' size='340' side='right'caption='[[3dxk]], [[Resolution|resolution]] 2.70Å' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[3dxk]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DXK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3DXK FirstGlance]. <br> | | <table><tr><td colspan='2'>[[3dxk]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DXK FirstGlance]. <br> |
| </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N23:N-[2-(2-METHYL-1H-INDOL-3-YL)ETHYL]THIOPHENE-2-CARBOXAMIDE'>N23</scene></td></tr> | | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> |
| <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3dxm|3dxm]]</td></tr> | | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N23:N-[2-(2-METHYL-1H-INDOL-3-YL)ETHYL]THIOPHENE-2-CARBOXAMIDE'>N23</scene></td></tr> |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3dxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dxk OCA], [http://pdbe.org/3dxk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dxk RCSB], [http://www.ebi.ac.uk/pdbsum/3dxk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dxk ProSAT]</span></td></tr> | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dxk OCA], [https://pdbe.org/3dxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dxk RCSB], [https://www.ebi.ac.uk/pdbsum/3dxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dxk ProSAT]</span></td></tr> |
| </table> | | </table> |
| == Function == | | == Function == |
| [[http://www.uniprot.org/uniprot/ARPC4_BOVIN ARPC4_BOVIN]] Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). [[http://www.uniprot.org/uniprot/ARPC2_BOVIN ARPC2_BOVIN]] Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). [[http://www.uniprot.org/uniprot/ARP3_BOVIN ARP3_BOVIN]] Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis (By similarity). [[http://www.uniprot.org/uniprot/ARC1B_BOVIN ARC1B_BOVIN]] Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). [[http://www.uniprot.org/uniprot/ARPC5_BOVIN ARPC5_BOVIN]] Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). [[http://www.uniprot.org/uniprot/ARP2_BOVIN ARP2_BOVIN]] Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. [[http://www.uniprot.org/uniprot/ARPC3_BOVIN ARPC3_BOVIN]] Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). | | [https://www.uniprot.org/uniprot/ARP3_BOVIN ARP3_BOVIN] Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis (By similarity). |
| == Evolutionary Conservation == | | == Evolutionary Conservation == |
| [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| </div> | | </div> |
| <div class="pdbe-citations 3dxk" style="background-color:#fffaf0;"></div> | | <div class="pdbe-citations 3dxk" style="background-color:#fffaf0;"></div> |
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| ==See Also==
| |
| *[[Biological Unit|Biological Unit]]
| |
| == References == | | == References == |
| <references/> | | <references/> |
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| [[Category: Bos taurus]] | | [[Category: Bos taurus]] |
| [[Category: Large Structures]] | | [[Category: Large Structures]] |
| [[Category: Hartman, J]] | | [[Category: Hartman J]] |
| [[Category: Jia, Z]] | | [[Category: Jia Z]] |
| [[Category: Nolen, B J]] | | [[Category: Nolen BJ]] |
| [[Category: Pierce, D W]] | | [[Category: Pierce DW]] |
| [[Category: Pollard, T D]] | | [[Category: Pollard TD]] |
| [[Category: Russell, A]] | | [[Category: Russell A]] |
| [[Category: Sakowicz, R]] | | [[Category: Sakowicz R]] |
| [[Category: Tomasevic, N]] | | [[Category: Tomasevic N]] |
| [[Category: Acetylation]]
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| [[Category: Actin-binding]]
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| [[Category: Atp-binding]]
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| [[Category: Beta-propeller]]
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| [[Category: Cell projection]]
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| [[Category: Cytoplasm]]
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| [[Category: Cytoskeleton]]
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| [[Category: Nucleotide-binding]]
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| [[Category: Phosphoprotein]]
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| [[Category: Structural protein]]
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| [[Category: Wd repeat]]
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