3ekr: Difference between revisions
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<StructureSection load='3ekr' size='340' side='right'caption='[[3ekr]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='3ekr' size='340' side='right'caption='[[3ekr]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ekr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3ekr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EKR FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=PY9:4-{[(2R)-2-(2-METHYLPHENYL)PYRROLIDIN-1-YL]CARBONYL}BENZENE-1,3-DIOL'>PY9</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ekr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ekr OCA], [https://pdbe.org/3ekr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ekr RCSB], [https://www.ebi.ac.uk/pdbsum/3ekr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ekr ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ekr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ekr OCA], [https://pdbe.org/3ekr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ekr RCSB], [https://www.ebi.ac.uk/pdbsum/3ekr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ekr ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Gajiwala | [[Category: Gajiwala KS]] | ||
Latest revision as of 13:08, 30 August 2023
Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone
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