5iri: Difference between revisions

<table><tr><td colspan='2'>[[5iri]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IRI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IRI FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5iri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iri OCA], [https://pdbe.org/5iri PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5iri RCSB], [https://www.ebi.ac.uk/pdbsum/5iri PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5iri ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/BRSK1_MOUSE BRSK1_MOUSE] Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-504' and 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.<ref>PMID:15705853</ref> <ref>PMID:17482548</ref> <ref>PMID:19648910</ref> <ref>PMID:20026642</ref>  

[[Category: Mus musculus]]

[[Category: Ma H]]

[[Category: Wang J]]

[[Category: Wu JW]]

[[Category: Wu JX]]