8fik: Difference between revisions

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'''Unreleased structure'''


The entry 8fik is ON HOLD  until Paper Publication
==APOBEC3A E72A inactive mutant in complex with ATTC-hairpin DNA substrate==
 
<StructureSection load='8fik' size='340' side='right'caption='[[8fik]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
Authors: Harjes, S., Jameson, G.B., Harjes, E., Filichev, V.V., Kurup, H.M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8fik]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FIK FirstGlance]. <br>
Description: APOBEC3A E72A inactive mutant in complex with ATTC-hairpin DNA substrate
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.912&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Kurup, H.M]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fik OCA], [https://pdbe.org/8fik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fik RCSB], [https://www.ebi.ac.uk/pdbsum/8fik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fik ProSAT]</span></td></tr>
[[Category: Jameson, G.B]]
</table>
[[Category: Harjes, E]]
== Function ==
[[Category: Filichev, V.V]]
[https://www.uniprot.org/uniprot/ABC3A_HUMAN ABC3A_HUMAN] DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.<ref>PMID:10469298</ref> <ref>PMID:12859895</ref> <ref>PMID:16527742</ref> <ref>PMID:19461882</ref> <ref>PMID:20615867</ref> <ref>PMID:20062055</ref> <ref>PMID:21496894</ref> <ref>PMID:21460793</ref> <ref>PMID:21123384</ref> <ref>PMID:21368204</ref> <ref>PMID:22896697</ref> <ref>PMID:22457529</ref>
[[Category: Harjes, S]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Filichev VV]]
[[Category: Harjes E]]
[[Category: Harjes S]]
[[Category: Jameson GB]]
[[Category: Kurup HM]]
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