8thu: Difference between revisions
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==Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1== | |||
<StructureSection load='8thu' size='340' side='right'caption='[[8thu]], [[Resolution|resolution]] 3.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8thu]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8THU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8THU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8thu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8thu OCA], [https://pdbe.org/8thu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8thu RCSB], [https://www.ebi.ac.uk/pdbsum/8thu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8thu ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Abini-Agbomson | == Function == | ||
[https://www.uniprot.org/uniprot/H2AZ_HUMAN H2AZ_HUMAN] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.<ref>PMID:15878876</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Xenopus laevis]] | |||
[[Category: Abini-Agbomson S]] | |||
[[Category: Armache K-J]] | |||
Latest revision as of 06:28, 6 September 2023
Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1
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